What are Bioregulators

What Are Peptide Bioregulators?

Peptides are a family of substances whose molecules are built from two or more amino acids. Peptides encompass around half of all known hormones and the majority of enzymes. However, there exists a distinct class of compounds known as peptide bioregulators, distinguished by their ability to initiate protein synthesis.

Peptide bioregulators are short chains of amino acids extracted from animal organs and tissues, belonging to the class of biologically active substances in pharmacology. They work by interacting with cellular receptors, enzymes, and other molecules to regulate various physiological processes. Bioregulators can help to optimize cellular metabolism, repair damaged tissues, enhance organ function, and support overall health and well-being.

Peptide absorption occurs in the small intestine due to the presence of macro- and microvilli and their contractile activity, dense networks of lymphatic and blood capillaries located beneath the basement membrane of enterocytes, and having a large number of wide pores (fenestrae) through which peptide molecules penetrate. So-called short peptides are considered to be poorly hydrolyzable compounds that maintain their structure during absorption in the gastrointestinal tract and thus exert their regulatory action.

How Do Khavinson Peptides Work?

The discovery of peptide bioregulators in the 1970s is credited to the eminent scientist and gerontologist, Professor Vladimir Khavinson, MD, PhD. Hence, they are often referred to as “Khavinson peptides”. Peptide bioregulators only affect the organ from which they were extracted. They are capable of restoring functional disorders and preventing pathological processes in the organs and tissues from which they were originally extracted. Bioregulators normalize protein synthesis, thereby preventing the accumulation of age-related changes that contribute to premature aging. They are used for prevention, adjunctive therapy, and maintaining the physiological functional activity of organs and systems in the body.

Where Are Khavinson Peptides Produced?

Peptides Company (Scientific Production Center for Revitalization and Health) is the official exclusive representative of the St. Petersburg Institute of Bioregulation and Gerontology in Russia and all Eurasian Economic Union countries since February 2010. All products of Peptides Company, including cosmetics, are manufactured in pharmacological production under the supervision and upon the order of the St. Petersburg Institute of Bioregulation and Gerontology.

Manufacturers of Khavinson peptides:

LLC “Farmakor Production” Pharmaceutical production of full-cycle biologically active supplements and medicinal products: formulation development, registration, manufacturing.
JSC “GNC PM Pharma”, is part of the MegaFarmUnion group of companies, specializing in contract manufacturing of dietary supplements, specialized nutrition products, and pharmaceuticals.
LLC “CBO Vita”, Chemico-Biological Association under the Russian Academy of Sciences “Vita” currently holds over 50 patents in the fields of cosmetology and medicine.
LLC “Sibfarmcontract”, an innovative full-cycle enterprise, one of the largest Russian manufacturers of dietary supplements and specialized nutrition products, as well as metabolic correction products.

Where Do Khavinson Peptides Come From In Cells?

The protein synthesized within a cell fulfills its function and afterward undergoes degradation. Enzymes called peptidases break it down into fragments. Some of these fragments are excreted from the body via the excretory system, while others undergo fragmentation. Certain fragments of the protein contain segments of amino acids connected in a specific way.

A bioregulator strictly corresponds to a specific segment of the DNA molecule. It aligns with this segment like a magnetic key signaling a magnetic lock to open a door. The DNA molecule unwinds, information is read from it, and cheat sheets (RNA) are constructed, which will be used to synthesize the protein—the very one that was previously degraded.

Consequently, bioregulatory peptides are formed from protein, but without them, the synthesis of the same protein is impossible.

What Are The Indications For Using Peptide Bioregulators?

Even under ideal conditions, a healthy body replenishes about 90% of the peptide deficit using its internal reserves, with the remaining 10% acquired from food. The problem arises when the body is subjected to stress factors:

Sedentary work
Poorly ventilated areas
Improper diet
Poor environmental conditions, etc.

Under the influence of these factors, organs and tissues gradually wear out, and they no longer receive enough peptides from food. In such cases, peptide supplements come to the rescue, temporarily replenishing this deficit.

Subsequently, when the tissue produces the necessary amount of required proteins, its function normalizes. However, if the body continues to be subjected to stress, the organs and tissues will malfunction again, requiring support once more.

Please note that peptide bioregulators cannot replace medications prescribed by a healthcare professional for the treatment of serious illnesses.

How To Take Peptide Bioregulators?

Peptide medications have a cumulative effect — each subsequent course is more effective than the previous one. After a 1–3 month course of peptides, their effects last for another six months. Therefore, to maintain organ function at an optimal level, it’s advisable to undergo two courses of peptide bioregulators per year.Peptide bioregulators are compatible not only with each other but also with traditional medications. Their intake can potentially minimize the dosage of the main therapeutic medication, of course, after examination and consultation with the attending physician.

When Peptide Bioregulators May Be Recommended?

Khavinson peptides are particularly relevant in mature age. Thus, it makes sense for everyone over the age of 30 to take peptide bioregulators. Additionally, they are worth considering for individuals who live or work in conditions of increased stress and poor environmental conditions, such as city dwellers, industrial workers, and office employees.

Bioregulators restore so-called “spines,” which stimulate the functioning of the neuronal network. Therefore, their intake not only increases lifespan but also prevents the development of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and others.

The older the person, the more visible the results, as the deficit of bioregulators increases with age.

Please remember that before deciding to take any medications, it is important to consult with a healthcare professional.

Why Can Peptide Bioregulators Be Taken Orally? Do They Not Get Destroyed In The Stomach?

Khavinson peptides are capable of maintaining their structure when absorbed in the gastrointestinal tract. This is possible because they are very short: their length does not exceed 20 amino acids, and the active site consists of only 2—3 amino acids. Such small structures do not break down in the digestive system and easily penetrate through the cell membrane.

Should Peptides Be Taken In The Morning Or Evening?

In principle, peptide bioregulators can be taken at any convenient time. The key is to establish a suitable regimen.

Peptide bioregulators (PBs) work slowly: the physiological effect occurs at least 3-4 hours after ingestion. This is because peptides need time to enter the bloodstream. Unlike hormones, which interact with the cell membrane like a pianist’s finger pressing a piano key, peptide bioregulators must penetrate the cell nucleus to activate its DNA.

Consequently, if peptide bioregulators are taken in the evening, the physiological effect will begin during the night. Therefore, they are usually taken in the morning or during the day. For example, clinical observations have shown that the greatest effect of taking a pineal gland peptide (reduced incidence of illness, increased melatonin production, etc.) was observed with morning administration.

Can Multiple Peptide Preparations Be Taken Simultaneously?

Since peptides act specifically, it is possible to use multiple preparations simultaneously. They are compatible with each other, do not interfere with each other, and can be combined with other medications, including pharmaceuticals. The only exception is that it is not recommended to take Glandokort (adrenal peptides) and Endoluten (pineal peptides) simultaneously.

Doctors may prescribe a course of several medications containing different peptides. However, specialists advise against taking more than five bioregulators simultaneously.

How Quickly Do Peptide Bioregulators Take Effect?

To feel the effects, a minimum course of peptides lasting 1 month is recommended. During this time, the cells of the body will partially regenerate. With Khavinson peptides, this regeneration will partially or fully restore the proper functioning of the organs, depending on the depth of the pathology.

What Happens If You Stop Taking Peptide Bioregulators? Will There Be Withdrawal Syndrome?

Peptides activate DNA and thereby initiate protein synthesis inside the cell, which is already occurring but less actively due to stress or peptide deficiency. Therefore, there will be no withdrawal syndrome, and the worst that can happen is that after the additional peptides disappear, the cell will return to its previous level of synthesis. However, as practice shows, it will be higher than the initial level.

Khavinson peptides are not hormones; they have a different mechanism of action and there is no withdrawal syndrome. By taking thyroid gland bioregulators, for example, you are not preventing the thyroid gland from functioning; you are simply helping it to naturally produce hormones in the required amount.

Do Peptides Cause Allergies, Mutations, Or Cancer?

Peptide bioregulators are not foreign substances and are not rejected by the body. The next-generation peptides developed by the Institute of Bioregulation and Gerontology are well purified, and they do not contain phospholipids – remnants of cell membranes. They are not foreign antigens, so there will be no immune response. There will be no allergic reactions, mutations will not occur because peptides only initiate the natural process of protein synthesis – the one that is inherent to the cell.

Is It Possible To Overdose On Peptides?

Overdosing is not possible – excess peptides will simply be excreted through the kidneys or intestines. An experiment was conducted on mice where the therapeutic dose of pancreatic peptides was exceeded by 100,000 times. There were no consequences.

Which Peptides Should Be Used In Sports?

Athletes take natural peptides:

Thymus peptides – to support the immune system and accelerate tissue regeneration in injuries,
Brain, peripheral and central nervous system peptides – for stress resistance,
Vascular peptides – for cardiovascular endurance,
Bone and cartilage peptides – for strengthening the musculoskeletal system, ligament reinforcement, and injury prevention.

The main advantage is that natural peptides сytomaxes and short synthesized peptides сytogens are not hormones or doping substances. They are food elements.

How Effective Are Peptide Bioregulators?

According to Dr. Roman Pinaev, a candidate of medical sciences and an oncologist, with over 30 years of clinical use, peptide bioregulators have shown high effectiveness across various diseases and pathological conditions. Approximately 15 million people have used peptides without any reported side effects or complications. They have no contraindications except for standard ones like individual intolerance to components, pregnancy, and breastfeeding periods. Peptides can be taken alongside most medications and any type of food.

To Sum Up

In this full review we have explored what peptide bioregulators are and provided answers to some of the most common questions about them.

It’s essential to note the words of the creator of peptide bioregulators, Khavinson, who emphasizes that
“It’s important to understand that a pill alone won’t save anyone. It’s primarily about lifestyle. It’s even believed that genetics only account for about 30% of lifespan, while 70% is determined by lifestyle. Therefore, the length of one’s life is in the hands of each individual.”

Adrenal

Enhances adrenal function, which in turn stimulates cortisol production to better manage stress reactions and decrease apathy. The Adrenal peptide bioregulator exhibits anti-autoimmune properties and regulates all endocrine processes in the body.

Bladder

Regulates bladder function, improving the metabolism of urinary bladder wall cells, thus enhancing flexibility and control. The Bladder peptide bioregulator possesses antioxidative properties, controlling oxidation in bladder wall tissues. It also alleviates overactive bladder syndrome (OBS) and benign prostate hyperplasia (BPH), enhancing urine flow and addressing chronic cystitis.

Blood Vessel

Normalizes and fortifies the vascular wall and heart valves, improving venous tone for better blood, nutrient, and oxygen circulation. The Blood Vessel peptide bioregulator enhances vein and capillary condition, optimizing blood pressure, microcirculation, and skin healing.

Bone Marrow

Balances bone marrow function, particularly red blood cell production, benefiting anemic and polycythemia patients, and boosting the hematopoietic system. It aids in rebuilding bone marrow post-illness or treatments that damage it.

Cartilage

Facilitates joint regeneration and bone metabolism normalization, reducing the risk of joint and spine diseases like osteoarthritis, spinal osteochondrosis, and osteoporosis. The Cartilage peptide bioregulator reduces pain and improves joint and vertebrae mobility.

CNS/Brain

Regulates brain cell and tissue function, enhancing brain cell oxygenation and slowing nerve tissue degeneration. It modulates inflammation, cell growth, and immune responses, aiding conditions like chronic fatigue syndrome, multiple sclerosis, depression, Parkinson’s, Alzheimer’s, and stress-related issues.

Heart

Normalizes and strengthens the heart muscle, regulating cardiovascular function, thus alleviating coronary artery disease, hypertension, hypertonia, myocarditis, atrial fibrillation, and heart failure, while also addressing stress.

Kidney

Normalizes kidney function, especially in gout nephropathy cases, reducing uric acid and urea levels. The Kidney peptide bioregulator may alleviate urothiasis disease, renal failure, and chronic pyelonephritis.

Liver

Regulates liver function, detoxifying, maintaining blood sugar levels, and performing vital functions, combating hepatitis, fatigue, and dyspeptic disorders. It may also benefit atherosclerosis, diabetes, and obesity.

Lungs

Improves lung function, protects bronchi and lungs, and increases lung elasticity, aiding conditions like chronic bronchitis, bronchial asthma, and pulmonary diseases.

Muscle

Enhances physical efficiency, muscle function under extreme conditions, and overall body mobility. The Muscle peptide bioregulator also acts as an antioxidant, regulating peroxidation processes in muscular tissues.

Ovary

Regulates ovarian function and hormone production, alleviating symptoms of perimenopause and menopause such as hot flashes, menstrual irregularities, poor sleep patterns, vaginal dryness, and low libido.

Pancreas

Normalizes pancreatic function, decreasing sugar levels in diabetic patients, and restoring pancreatic tissue in chronic pancreatitis cases. It also promotes gastrointestinal mucosa regeneration and normalizes pancreatic and biliary tract function.

Parathyroid

Normalizes parathyroid gland function, enhancing calcium production in blood and bones, benefiting hyperparathyroidism, hypoparathyroidism, osteoporosis, and poor vitamin D absorption.

Pineal

Regulates neuroendocrine system function, lengthening telomeres, and improving synthesis of serotonin and melatonin, enhancing libido and hormonal status while improving pineal gland health.

Prostate

Improves prostate gland function, reducing BPH, inflammation, prostatitis, and prostate cancer.

Retina

Prevents retinal degeneration, aiding in the repair of retinal damage caused by diseases like diabetic retinopathy, pigment retinitis, and myopia.

Stomach

Promotes gastric and duodenal mucosa healing, normalizes digestion, and prevents gastric ulcers and polyps. It also alleviates heartburn, belching, and stomach heaviness.

Testes

Enhances hormonal status and spermatogenesis, addressing issues like libido, erectile dysfunction, and male infertility.

Thymus

Regulates immune status, stimulates regeneration, and exhibits anti-atherogenic, anti-coagulant, anti-autoimmune, and oncoprotective effects, aiding in immune system restoration post-radiation, chemotherapy, and infectious diseases.

Thyroid

Normalizes thyroid gland function, preventing nodules, hyperthyroidism, and hypothyroidism.